Senior Manager/Associate Director, Information Technology
Nkartatherapeutics · South San Francisco
About this role
**About Nkarta** Nkarta is a publicly traded (Nasdaq: NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease. Founded in 2015, Nkarta’s mission is to harness the body’s natural killer cells to deliver a safe, accessible form of cell therapy for B cell–mediated autoimmune diseases. The company’s vision is to make cell therapy more broadly available by pioneering allogeneic NK cells that can be dosed in outpatient, community health settings. **Overview** Nkarta is seeking a hands-on **Senior Manager / Associate Director, Information Technology** to lead the company’s IT function as the organization advances its lead NK cell therapy candidate toward pivotal and Phase 3 clinical trials. This role serves as the head of the Information Technology department, reporting to the SVP, Head of Operations, and is responsible for the strategy, infrastructure, security, and compliance of IT systems supporting manufacturing, quality, clinical, scientific, and corporate operations. This is a true working leadership role—supporting day-to-day IT needs while directly managing **one IT FTE** and overseeing an outsourced IT consulting firm/managed service provider (MSP). **Responsibilities** - Serve as the head of the Information Technology function, owning IT strategy, infrastructure, systems, and security. - Operate in a hands-on capacity: day-to-day IT operations, end-user support, and technical troubleshooting. - Directly manage and develop one IT FTE; oversee the performance, deliverables, and relationship with an outsourced IT consulting firm/MSP. - Design, implement, and maintain network, server, cloud, and end-user computing infrastructure to support a growing clinical-stage organization. - Own the cybersecurity program (endpoint protection, identity & access management, vulnerability management, security awareness training, incident response). - Ensure computer systems used in GxP-regulated processes are validated and maintained in compliance with **21 CFR Part 11**, data integrity, and other applicable regulatory requirements. - Administer and support core business and scientific applications (e.g., Microsoft 365, ERP, lab systems, eQMS) in partnership with functional business owners. - Manage the IT budget, vendor contracts, and software licensing; oversee the IT consulting firm’s statement of work, service levels, and performance. - Partner cross-functionally with Manufacturing, Clinical Operations, Quality, Regulatory, R&D, Finance, and HR to ensure IT systems and data support pivotal trial transition and commercialization. - Develop and maintain business continuity and disaster recovery plans. - Support **SOX IT general controls** and coordinate with Finance and external auditors. - Establish and maintain IT policies, procedures, and change control processes appropriate for a scaling, regulated biotech company. - Lead technology onboarding/offboarding and hardware/software lifecycle management for all employees. **Qualifications** - Demonstrated experience supporting an evolving clinical-stage company, including scaling IT systems and infrastructure under increasing regulatory/operational demands. - Hands-on expertise managing network, server, cloud (e.g., AWS, Azure), and end-user computing environments. - Strong knowledge of computer system validation (CSV), 21 CFR Part 11, GxP requirements, and data i
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