Senior Computational Scientist
Twistbioscience · USA - South San Francisco, CA
About this role
**Senior Computational Scientist, AI for Protein Design and Discovery** **About the role** Twist is seeking a Senior or Staff Computational Scientist to develop AI and computational solutions for protein design, discovery, and characterization. You will work across computational biology, machine learning, and experimental science, collaborating with research scientists, software engineers, and customer-facing teams. **What you'll do** • Develop algorithms integrating protein sequences with NGS and experimental data • Identify high-impact opportunities for new algorithms and AI-enabled capabilities • Develop AI/ML methods for designing, evaluating, and optimizing therapeutic protein sequences • Apply protein language models (PLMs) to sequence generation, property prediction, and candidate prioritization • Partner with software and bioinformatics teams to integrate models into scalable research systems • Lead computational analyses for protein discovery programs • Collaborate across teams to translate scientific needs into practical solutions • Move flexibly between research, software development, analysis, and troubleshooting **What you'll bring** • Minimum 5 years industry experience with a PhD • PhD in computational biology, bioinformatics, machine learning, computer science, protein science, or related field • Extensive experience developing algorithms for protein design, engineering, discovery, or sequence analysis • Demonstrated experience with AI/ML methods applied to proteins or biological sequences • Strong understanding of protein language models and sequence-structure-function relationships • Experience analyzing NGS data from biological selection or screening workflows • Strong Python skills and experience with PyTorch or TensorFlow • Record of translating scientific questions into validated computational methods • Strong cross-functional communication and scientific judgment **Preferred qualifications** • Experience with antibody discovery, engineering, or characterization • Experience with biopanning or display-based discovery platforms • Experience integrating protein sequence, NGS, and experimental assay data • Experience with generative protein design or property prediction methods **Compensation** (San Francisco Bay Area): $150,700 – $180,800 USD Twist Bioscience is an Equal Opportunity Employer.
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